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KMID : 1145520200060020107
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Journal of Radiopharmaceuticals and Molecular Probes
2020 Volume.6 No. 2 p.107 ~ p.112
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Development of radiolabelled histone deacetylase inhibitors for PET imaging study
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Kim Hee-Kwon
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Abstract
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Histone Deacetylases (HDACs) are enzymes that have control gene expression regulation and cell state. In additions, inhibitions of HDACs are associated with growth arrest, differentiation, or apoptosis of tumor cell. Thus HDAC inhibition is one of the interesting biological targets. A variety of HDAC inhibitors has been developed by many scientists, and some of chemical structures related with HDAC inhibitors were modified to give radiolabeled HDAC inhibitors for positron emission tomography (PET) study. In this highlight review, the development of radiolabeled HDAC inhibitors for PET study are described.
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KEYWORD
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Histone deacetylase, HDAC inhibitor, Positron emission tomography (PET)
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